Tumor microenvironment and progression.

TitleTumor microenvironment and progression.
Publication TypeJournal Article
Year of Publication2011
AuthorsDvorak HF, Weaver VM, Tlsty TD, Bergers G
JournalJ Surg Oncol
Volume103
Issue6
Pagination468-74
Date Published2011 May 1
ISSN1096-9098
KeywordsAngiogenesis Inhibitors, Breast Neoplasms, Disease Progression, Female, Humans, Molecular Targeted Therapy, Neoplasm Invasiveness, Neoplasms, Neovascularization, Pathologic, Tumor Microenvironment, Vascular Endothelial Growth Factor A
Abstract

Tumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor-A (VEGF-A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis. Also, breast cancers arise as the result of epigenetic as well as genetic changes. Tumor blood vessel pericytes result, in part, from bone marrow precursor cells, and VEGF is a negative regulator of glioblastoma tumor cell invasion.

DOI10.1002/jso.21709
Alternate JournalJ Surg Oncol
PubMed ID21480238
PubMed Central IDPMC3277953
Grant ListCA097214 / CA / NCI NIH HHS / United States
CA122024 / CA / NCI NIH HHS / United States
HL-64402 / HL / NHLBI NIH HHS / United States
P01 CA092644 / CA / NCI NIH HHS / United States
P01 CA092644-01A1 / CA / NCI NIH HHS / United States
P01 CA92644 / CA / NCI NIH HHS / United States
R01 CA109390 / CA / NCI NIH HHS / United States
R01 CA113382 / CA / NCI NIH HHS / United States
R01 CA138818 / CA / NCI NIH HHS / United States
R01 CA142262 / CA / NCI NIH HHS / United States
R01 CA142262-03 / CA / NCI NIH HHS / United States
R01 HL054465-04 / HL / NHLBI NIH HHS / United States
T32 CA009043 / CA / NCI NIH HHS / United States
T32 HL007893 / HL / NHLBI NIH HHS / United States
T32 HL007893-01 / HL / NHLBI NIH HHS / United States
U54CA143836-01 / CA / NCI NIH HHS / United States