@article {316,
	title = {Balancing forces: architectural control of mechanotransduction.},
	journal = {Nat Rev Mol Cell Biol},
	volume = {12},
	year = {2011},
	month = {2011 May},
	pages = {308-19},
	abstract = {<p>All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations to mechanotransduction, from the nanoscale-level to the tissue-level, which compromises tensional homeostasis to promote pathologies such as cardiovascular disease and cancer. The mechanisms of such perturbations suggest that a complex interplay exists between the extracellular microenvironment and cellular function. Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.</p>
},
	keywords = {Animals, Cell Adhesion, Extracellular Matrix, Homeostasis, Humans, Intercellular Junctions, Mechanotransduction, Cellular, Models, Biological, Stress, Mechanical},
	issn = {1471-0080},
	doi = {10.1038/nrm3112},
	author = {DuFort, Christopher C and Paszek, Matthew J and Weaver, Valerie M}
}
