Congratulations to Matt Rubashkin and coauthors on their publication in Cancer Research!
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Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.. J Cell Biol. 163(6):1397-407.. 2003.
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.. J Cell Sci. 120(Pt 20):3700-12.. 2007.