Congratulations to Matthew Paszek (now at Cornell University) and all other authors on their recent publication in Nature!
Biblio
Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties.. Phys Biol. 8(2):026013.
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2011. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis.. J Cell Physiol. 225(1):115-22.
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2010. Dynamic interplay between the collagen scaffold and tumor evolution.. Curr Opin Cell Biol. 22(5):697-706.
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2010. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.. J Cell Sci. 109 ( Pt 1):45-56.
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1996. Deconstructing Signaling in 3 Dimensions.. Biochemistry.
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2014. Death in the third dimension: apoptosis regulation and tissue architecture.. Curr Opin Genet Dev. 14(1):71-80.
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2004. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.. Cancer Epidemiol Biomarkers Prev. 18(3):901-14.
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2009. Collagen architecture in pregnancy-induced protection from breast cancer.. J Cell Sci. 126(Pt 18):4108-10.
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2013. The cancer glycocalyx mechanically primes integrin-mediated growth and survival.. Nature. 511(7509):319-25.
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2014. Biomechanical regulation of cell orientation and fate.. Oncogene. 27(55):6981-93.
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2008. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.. Cancer Cell. 2(3):205-16.
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2002. Balancing forces: architectural control of mechanotransduction.. Nat Rev Mol Cell Biol. 12(5):308-19.
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2011. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.. J Cell Biol. 163(6):1397-407.
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2003. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.. J Cell Sci. 120(Pt 20):3700-12.
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2007. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.. Cancer Cell. 19(6):776-91.
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2011. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.. J Biotechnol. 193:66-9.
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2015.