Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.

TitleFighting the force: Potential of homeobox genes for tumor microenvironment regulation.
Publication TypeJournal Article
Year of Publication2015
AuthorsNorthcott JM, Northey JJ, J Barnes M, Weaver VM
JournalBiochim Biophys Acta
Volume1855
Issue2
Pagination248-253
Date Published2015 Apr
ISSN0006-3002
Abstract

Tumor cells exist in a constantly evolving stromal microenvironment composed of vasculature, immune cells and cancer-associated fibroblasts, all residing within a dynamic extracellular matrix. In this review, we examine the biochemical and biophysical interactions between these various stromal cells and their matrix microenvironment. While the stroma can alter tumor progression via multiple mechanisms, we emphasize the role of homeobox genes in detecting and modulating the mechanical changes in the microenvironment during tumor progression.

DOI10.1016/j.bbcan.2015.03.004
Alternate JournalBiochim. Biophys. Acta
PubMed ID25818365
PubMed Central IDPMC4433566
Grant ListF32 CA174319 / CA / NCI NIH HHS / United States
R01 CA085492 / CA / NCI NIH HHS / United States
R01 CA138818 / CA / NCI NIH HHS / United States
R01 CA174929 / CA / NCI NIH HHS / United States
R01 CA192914 / CA / NCI NIH HHS / United States
R33 CA183685 / CA / NCI NIH HHS / United States
U01 CA151925 / CA / NCI NIH HHS / United States
U54 CA163155 / CA / NCI NIH HHS / United States