Dynamic interplay between the collagen scaffold and tumor evolution.

TitleDynamic interplay between the collagen scaffold and tumor evolution.
Publication TypeJournal Article
Year of Publication2010
AuthorsEgeblad M, Rasch MG, Weaver VM
JournalCurr Opin Cell Biol
Volume22
Issue5
Pagination697-706
Date Published2010 Oct
ISSN1879-0410
KeywordsCell Movement, Collagen, Humans, Neoplasms, Tissue Scaffolds
Abstract

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the ECM has been thought of primarily as a physical scaffold that binds cells and tissues together. However, the ECM also elicits biochemical and biophysical signaling. Controlled proteolysis and remodeling of the ECM network regulate tissue tension, generate pathways for migration, and release ECM protein fragments to direct normal developmental processes such as branching morphogenesis. Collagens are major components of the ECM of which basement membrane type IV and interstitial matrix type I are the most prevalent. Here we discuss how abnormal expression, proteolysis and structure of these collagens influence cellular functions to elicit multiple effects on tumors, including proliferation, initiation, invasion, metastasis, and therapy response.

DOI10.1016/j.ceb.2010.08.015
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID20822891
PubMed Central IDPMC2948601
Grant ListCA138818-01A1 / CA / NCI NIH HHS / United States
R01 CA138818 / CA / NCI NIH HHS / United States
R01 CA138818-01A1 / CA / NCI NIH HHS / United States
R01 CA138818-03 / CA / NCI NIH HHS / United States
U01 CA141451-01 / CA / NCI NIH HHS / United States
U01CA141451 / CA / NCI NIH HHS / United States
U54 CA143836-01 / CA / NCI NIH HHS / United States
U54CA143836 / CA / NCI NIH HHS / United States