Extracellular matrix assembly: a multiscale deconstruction.

TitleExtracellular matrix assembly: a multiscale deconstruction.
Publication TypeJournal Article
Year of Publication2014
AuthorsMouw JK, Ou G, Weaver VM
JournalNat Rev Mol Cell Biol
Date Published2014 Nov 5

The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.

Alternate JournalNat. Rev. Mol. Cell Biol.
PubMed ID25370693