|Title||Extracellular matrix assembly: a multiscale deconstruction.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Mouw JK, Ou G, Weaver VM|
|Journal||Nat Rev Mol Cell Biol|
|Date Published||2014 Nov 5|
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.
|Alternate Journal||Nat. Rev. Mol. Cell Biol.|