Extracellular matrix degradation and remodeling in development and disease.

TitleExtracellular matrix degradation and remodeling in development and disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsLu P, Takai K, Weaver VM, Werb Z
JournalCold Spring Harb Perspect Biol
Volume3
Issue12
Date Published2011 Dec
ISSN1943-0264
KeywordsAnimals, Body Patterning, Cell Differentiation, Extracellular Matrix, Extracellular Matrix Proteins, Mice, Models, Biological, Neoplasms, Peptide Hydrolases, Signal Transduction, Stem Cells, Vertebrates
Abstract

The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture. ECM remodeling is an important mechanism whereby cell differentiation can be regulated, including processes such as the establishment and maintenance of stem cell niches, branching morphogenesis, angiogenesis, bone remodeling, and wound repair. In contrast, abnormal ECM dynamics lead to deregulated cell proliferation and invasion, failure of cell death, and loss of cell differentiation, resulting in congenital defects and pathological processes including tissue fibrosis and cancer. Understanding the mechanisms of ECM remodeling and its regulation, therefore, is essential for developing new therapeutic interventions for diseases and novel strategies for tissue engineering and regenerative medicine.

DOI10.1101/cshperspect.a005058
Alternate JournalCold Spring Harb Perspect Biol
PubMed ID21917992
PubMed Central IDPMC3225943
Grant ListR01 CA057621 / CA / NCI NIH HHS / United States
R01 CA057621 / CA / NCI NIH HHS / United States
R01 CA138818 / CA / NCI NIH HHS / United States
R01 CA138818 / CA / NCI NIH HHS / United States
R03 HD060807 / HD / NICHD NIH HHS / United States
U01 ES019458 / ES / NIEHS NIH HHS / United States
U01 ES019458 / ES / NIEHS NIH HHS / United States