Integrin-mediated signalling through the MAP-kinase pathway.

TitleIntegrin-mediated signalling through the MAP-kinase pathway.
Publication TypeJournal Article
Year of Publication2008
AuthorsYee KL, Weaver VM, Hammer DA
JournalIET Syst Biol
Date Published2008 Jan
KeywordsAnimals, Humans, Integrins, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases, Models, Biological, ras Proteins

The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK are mediated by differences in ERK signalling dynamics, including magnitude and duration. In vivo, ERK signalling is stimulated by both growth factors and adhesion signals. A model for adhesion-mediated ERK activation is presented. Outputs of the model such as ERK and FAK activation, as well as responses to different ligand densities, are compared with published experimental data. The model then serves as a basis for understanding how adhesion may contribute to ERK signalling through changes in the dynamics of focal adhesion kinase activation. The main parameters influencing ERK are determined through screening analyses and parameter variation. With these parameters, key points in the pathway that give rise to changes in downstream signalling dynamics are identified. In particular, oncogenic Raf and Ras promote cell growth by increasing the magnitude and duration, respectively, of ERK activity.

Alternate JournalIET Syst Biol
PubMed ID18248081