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YAP forces fibroblasts to feel the tension.

TitleYAP forces fibroblasts to feel the tension.
Publication TypeJournal Article
Year of Publication2013
AuthorsMaller O, DuFort CC, Weaver VM
JournalNat Cell Biol
Volume15
Issue6
Pagination570-2
Date Published2013 Jun
ISSN1476-4679
KeywordsAdaptor Proteins, Signal Transducing, Animals, Breast Neoplasms, Female, Fibroblasts, Humans, Mechanotransduction, Cellular, Phosphoproteins
Abstract

Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and remodelling. However, how CAFs become activated and their roles in tumour mechanics have remained unclear. YAP is now identified as a tension-stimulated CAF activator that promotes malignancy through a mechanically reinforced feed-forward loop.
DOI10.1038/ncb2777
Alternate JournalNat. Cell Biol.
PubMed ID23728464